PhD Projects
1.1 Models of chronicity, sequestration, treatment response and recrudescence
London School of Hygiene and Tropical Medicine (LSHTM), London, United Kingdom || Instituto de Higiene e Medicina Tropical (IHMT), Lisboa, Portugal - Microsens Diagnostic Ltd., London, United Kingdom
First comparison of the vigour of hybrid, non-hybrid and virus infected Leishmania genotypes in vivo by bioluminescence imaging. Unique insight into the dynamics of parasite sequestration and recrudescence/relapse following treatment failure.
Area of research: Diagnostic/Treatment
Research programme: Basic Science
1.2 Estimation of the risk of developing resistance to antileishmanial drugs
London School of Hygiene and Tropical Medicine (LSHTM), London, United Kingdom - Institute of Tropical Medicine (ITM), Antwerp, Belgium || GlaxoSmithKline (GSK), Tres Cantos (Madrid), Spain - Wellcome Trust Sanger Institute (WTSI), Hinxton, United Kingdom
Assessing the relevance of drug resistance studies in the R&D pipeline for new drugs
Area of research: Diagnostic/Treatment
Research programme: Basic Science
1.3 Novel models for the development of treatments for Cutaneous Leishmaniasis
London School of Hygiene and Tropical Medicine (LSHTM), London, United Kingdom || Instituto de Higiene e Medicina Tropical (IHMT), Lisboa, Portugal - Pharmidex Pharmaceutical Services Ltd., London, United Kingdom - University College London (UCL), London, United Kingdom
Area of research: Diagnostic/Treatment
Research programme: Basic Science
1.4 Strategies for improving differential diagnosis and providing biomarkers
Coris BioConcept (CORIS), Gembloux, Belgium - London School of Hygiene and Tropical Medicine (LSHTM), London, United Kingdom || Aptum Biologics Ltd. (APTUM), Southamptom, United Kingdom - Karolinska Institutet (KI), Stockholm, Sweden
Area of research: Diagnostic/Treatment
Research programme: Translational Science
1.5 Diagnostic mimotopes for antibody detection in visceral leishmaniasis
Coris BioConcept (CORIS), Gembloux, Belgium - Institute of Tropical Medicine (ITM), Antwerp, Belgium || University of Gondar (GONDAR), Gondar, Ethiopia
To develop a rapid diagnostic test for VL serodiagnosis with high diagnostic accuracy in East-Africa
Area of research: Diagnostic/Treatment
Research programme: Translational Science
1.6 Economic and business impact evaluation of Public-Private Partnerships for the development of drugs and diagnostic tools for leishmaniasis and other neglected tropical diseases (NTDs)
Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain || Swiss Tropical and Public Health Institute (STPH), Basel, Switzerland - Foundation for Innovative New Diagnostics (FIND), Geneva, Switzerland
Area of research: Diagnostic/Treatment
Research programme: Implementation
1.7 Access to care for leishmaniasis in Africa
Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain - Institute of Tropical Medicine (ITM), Antwerp, Belgium || Médecins Sans Frontières (MSF), Geneva, Switzerland - University of Gadarif (UoG), Gadarif (Al Qadarif), Sudan
Describe current barriers to leishmaniasis treatment in Africa and suggest new strategies to enhance access to care in endemic communities
Area of research: Diagnostic/Treatment
Research programme: Implementation
1.8 A Leishmania knowledge center to support health care professionals and patients
Institute of Tropical Medicine (ITM), Antwerp, Belgium - BMD Software (BMD), Aveiro, Portugal || University of Gondar (GONDAR), Gondar, Ethiopia
This international project aims investigating and developing an Epi-surveillance knowledge system for neglected tropical diseases, which is able to gather and process biomedical data (EHR, images, scientific documents, knowledge databases)
Area of research: Diagnostic/Treatment
Research programme: Implementation
2.1 Development of a multi-epitope peptide vaccine against human leishmaniasis
Institut de recherche pour le développement (IRD), Montpellier, France || Institut Pasteur de Tunis (IPT), Tunisia, Tunis - Synprosis cGMP, Fuveau, France
Area of research: Prevention
Research programme: Basic Science
2.2 Development of a recombinant vaccine against canine leishmaniasis. From differential gene expression to the field
London School of Hygiene and Tropical Medicine (LSHTM), London, United Kingdom - Institute of Tropical Medicine (ITM), Antwerp, Belgium - Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain || CZ Veterinaria S.A., O Porriño, Spain
The development of a protective DNA vaccine against canine leishmaniasis is being carried out. The induction of a Th1 protective answer at the dogs will be assessed. The vaccine production as well as the scaling up methods under GMP conditions will also be developed.
Area of research: Prevention
Research programme: Basic Science
2.3 Developing and evaluating new tools to study Leishmania transmission from sandflies
London School of Hygiene and Tropical Medicine (LSHTM), London, United Kingdom || Biogents AG, Regensburg, Germany
Area of research: Prevention
Research programme: Translational Science
2.4 Systemic insecticides in dogs to control zoonotic visceral leishmaniasis
Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain - The University of Warwick (WARWICK), Coventry, United Kingdom || Universidad de Zaragoza (UNIZAR), Zaragoza, Spain - Verdi R&D, Louveigné, Belgium
Area of research: Prevention
Research programme: Translational Science
2.5 New methods to identify leishmania super-spreaders in modelling targeted control
The University of Warwick (WARWICK), Coventry, United Kingdom || INBios International, Inc., Seattle, USA - Infectious Disease Research Institute (IDRI), Seattle, USA
To identify differential diagnostic antigens for canine super-spreaders and to model impacts on transmission of visceral leishmaniasis
Area of research: Prevention
Research programme: Translational Science
2.6 Development of new sand fly exposure markers to evaluate vector control tools
Charles University in Prague (CUNI), - Coris BioConcept (CORIS), Gembloux, Belgium - Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain
Sand fly salivary antigens as a tool for determination of host exposure to sand fly bites
Area of research: Prevention
Research programme: Translational Science
2.7 Evaluation of canine leishmaniasis vaccine under field conditions in Spain
Charles University in Prague (CUNI), - Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain || Clínica Veterinaria CANIS, Girona, Spain - Universitat de Barcelona (UB), Barcelona, Spain
Area of research: Prevention
Research programme: Implementation
