PhD Projects

1.1 Models of chronicity, sequestration, treatment response and recrudescence

London School of Hygiene and Tropical Medicine (LSHTM), London, United Kingdom || Instituto de Higiene e Medicina Tropical (IHMT), Lisboa, Portugal - Microsens Diagnostic Ltd., London, United Kingdom


First comparison of the vigour of hybrid, non-hybrid and virus infected Leishmania genotypes in vivo by bioluminescence imaging. Unique insight into the dynamics of parasite sequestration and recrudescence/relapse following treatment failure.


Area of research: Diagnostic/Treatment

Research programme: Basic Science


1.2 Estimation of the risk of developing resistance to antileishmanial drugs

London School of Hygiene and Tropical Medicine (LSHTM), London, United Kingdom - Institute of Tropical Medicine (ITM), Antwerp, Belgium || GlaxoSmithKline (GSK), Tres Cantos (Madrid), Spain - Wellcome Trust Sanger Institute (WTSI), Hinxton, United Kingdom


Assessing the relevance of drug resistance studies in the R&D pipeline for new drugs


Area of research: Diagnostic/Treatment

Research programme: Basic Science


1.3 Novel models for the development of treatments for Cutaneous Leishmaniasis

London School of Hygiene and Tropical Medicine (LSHTM), London, United Kingdom || Instituto de Higiene e Medicina Tropical (IHMT), Lisboa, Portugal - Pharmidex Pharmaceutical Services Ltd., London, United Kingdom - University College London (UCL), London, United Kingdom



Area of research: Diagnostic/Treatment

Research programme: Basic Science


1.4 Strategies for improving differential diagnosis and providing biomarkers

Coris BioConcept (CORIS), Gembloux, Belgium - London School of Hygiene and Tropical Medicine (LSHTM), London, United Kingdom || Aptum Biologics Ltd. (APTUM), Southamptom, United Kingdom - Karolinska Institutet (KI), Stockholm, Sweden



Area of research: Diagnostic/Treatment

Research programme: Translational Science


1.5 Diagnostic mimotopes for antibody detection in visceral leishmaniasis

Coris BioConcept (CORIS), Gembloux, Belgium - Institute of Tropical Medicine (ITM), Antwerp, Belgium || University of Gondar (GONDAR), Gondar, Ethiopia


To develop a rapid diagnostic test for VL serodiagnosis with high diagnostic accuracy in East-Africa


Area of research: Diagnostic/Treatment

Research programme: Translational Science


1.6 Economic and business impact evaluation of Public-Private Partnerships for the development of drugs and diagnostic tools for leishmaniasis and other neglected tropical diseases (NTDs)

Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain || Swiss Tropical and Public Health Institute (STPH), Basel, Switzerland - Foundation for Innovative New Diagnostics (FIND), Geneva, Switzerland



Area of research: Diagnostic/Treatment

Research programme: Implementation


1.7 Access to care for leishmaniasis in Africa

Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain - Institute of Tropical Medicine (ITM), Antwerp, Belgium || Médecins Sans Frontières (MSF), Geneva, Switzerland - University of Gadarif (UoG), Gadarif (Al Qadarif), Sudan


Describe current barriers to leishmaniasis treatment in Africa and suggest new strategies to enhance access to care in endemic communities


Area of research: Diagnostic/Treatment

Research programme: Implementation


1.8 A Leishmania knowledge center to support health care professionals and patients

Institute of Tropical Medicine (ITM), Antwerp, Belgium - BMD Software (BMD), Aveiro, Portugal || University of Gondar (GONDAR), Gondar, Ethiopia


This international project aims investigating and developing an Epi-surveillance knowledge system for neglected tropical diseases, which is able to gather and process biomedical data (EHR, images, scientific documents, knowledge databases)


Area of research: Diagnostic/Treatment

Research programme: Implementation


2.1 Development of a multi-epitope peptide vaccine against human leishmaniasis

Institut de recherche pour le développement (IRD), Montpellier, France || Institut Pasteur de Tunis (IPT), Tunisia, Tunis - Synprosis cGMP, Fuveau, France



Area of research: Prevention

Research programme: Basic Science


2.2 Development of a recombinant vaccine against canine leishmaniasis. From differential gene expression to the field

London School of Hygiene and Tropical Medicine (LSHTM), London, United Kingdom - Institute of Tropical Medicine (ITM), Antwerp, Belgium - Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain || CZ Veterinaria S.A., O Porriño, Spain


The development of a protective DNA vaccine against canine leishmaniasis is being carried out. The induction of a Th1 protective answer at the dogs will be assessed. The vaccine production as well as the scaling up methods under GMP conditions will also be developed.


Area of research: Prevention

Research programme: Basic Science


2.3 Attractive toxic sugar baits (ATSB) for indoor use: The design and evaluation of a novel approach for controlling sand fly vectors of leishmaniasis

London School of Hygiene and Tropical Medicine (LSHTM), London, United Kingdom || Biogents AG, Regensburg, Germany



Area of research: Prevention

Research programme: Translational Science


2.4 Systemic insecticides in dogs to control zoonotic visceral leishmaniasis

Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain - The University of Warwick (WARWICK), Coventry, United Kingdom || Universidad de Zaragoza (UNIZAR), Zaragoza, Spain - Verdi R&D, Louveigné, Belgium



Area of research: Prevention

Research programme: Translational Science


2.5 New methods to identify leishmania super-spreaders in modelling targeted control

The University of Warwick (WARWICK), Coventry, United Kingdom || INBios International, Inc., Seattle, USA - Infectious Disease Research Institute (IDRI), Seattle, USA


To identify differential diagnostic antigens for canine super-spreaders and to model impacts on transmission of visceral leishmaniasis


Area of research: Prevention

Research programme: Translational Science


2.6 Development of new sand fly exposure markers to evaluate vector control tools

Charles University in Prague (CUNI), - Coris BioConcept (CORIS), Gembloux, Belgium - Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain


Sand fly salivary antigens as a tool for determination of host exposure to sand fly bites


Area of research: Prevention

Research programme: Translational Science


2.7 Evaluation of canine leishmaniasis vaccine under field conditions in Spain

Charles University in Prague (CUNI), - Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain || Clínica Veterinaria CANIS, Girona, Spain - Universitat de Barcelona (UB), Barcelona, Spain



Area of research: Prevention

Research programme: Implementation